Liver Preparation

The unbound fraction of taurocholate for each of five concentrations of administered taurocholate.

Usage

LiverPreparation

Format

A data frame with 5 observations on the following 2 variables.

concentration

a numeric vector

unbound.fraction

a numeric vector

Source

Smallwood, R.H., D.J. Morgan, G.W. Mihaly, and R.A. Smallwood. 1998. Effect of a protein binding change on unbound and total plasma concentrations for drugs of intermediate hepatic extraction. Journal of Pharmacokinetics and Pharmacodynamics 16:397-411.

References

http://www.ncbi.nlm.nih.gov/pubmed/3199317

Examples

str(LiverPreparation)
#> 'data.frame':	5 obs. of  2 variables:
#>  $ concentration   : num  2.8 5.8 12 23.9 47.8
#>  $ unbound.fraction: num  0.63 0.44 0.31 0.19 0.13
xyplot(unbound.fraction ~ concentration, LiverPreparation)